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Monday, July 27, 2020 | History

1 edition of Live variola virus found in the catalog.

Live variola virus

Ann M. Arvin

Live variola virus

considerations for continuing research

by Ann M. Arvin

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  • 21 Currently reading

Published by National Academies Press in Washington, D.C .
Written in English


Edition Notes

Includes bibliographical references.

StatementCommittee on the Assessment of Future Scientific Needs for Live Variola Virus, Board on Global Health, Institute of Medicine of the National Academies ; Ann M. Arvin and Deepali M. Patel, editors
ContributionsInstitute of Medicine (U.S.). Committee on the Assessment of Future Scientific Needs for Live Variola Virus
Classifications
LC ClassificationsRC183 .L73 2009
The Physical Object
Paginationxvii, 151 p. :
Number of Pages151
ID Numbers
Open LibraryOL24385454M
ISBN 100309136903
ISBN 109780309136907
LC Control Number2010286892
OCLC/WorldCa431193646

  The disease, caused by the variola virus, covers the body with painful sores. It was declared eradicated in after a worldwide vaccination .   Variola virus DNA found in bones of people from Denmark to Russia around Viking era Nicola Davis Massacred 10th century Vikings are seen having been found in a .

All work with live variola virus is done under biosafety level 4 containment conditions at CDC. Smallpox virus is officially retained at only two facilities in the world: at CDC in the United States and the State Research Center of Virology and Biotechnology in Novosibirsk, Russia. Objectives of the program derive from a Institute of Medicine report that addressed the scientific needs for live variola virus. Progress in addressing these objectives has been peer reviewed annually by both a select committee organized by CDC and the World Health Organization (WHO) Advisory Committee on Variola Virus Research (2,3).

  Others, however, warn that labeling possession of the virus a crime against humanity will in no way deter terrorists, and that without the live smallpox virus, called variola, we won't be able to.   The variola virus causes it. There are two forms of the virus. The more dangerous form, variola major, led to smallpox disease that killed about 30% of people who were infected.


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Live variola virus by Ann M. Arvin Download PDF EPUB FB2

Assessment of Future Scientific Needs for Live Variola Virus - NCBI Bookshelf. Inthe World Health Organization (WHO) officially declared that smallpox had been eradicated.

InWHO's international Ad Hoc Committee on Orthopox Virus Infections unanimously recommended destruction of the two remaining official stocks of variola virus, one Live variola virus book the Centers for Disease Control and.

ISBN: OCLC Number: Description: xvii, pages: illustrations: Contents: Introduction --Overview of smallpox and its surveillance and control --Comparative poxvirology --Animal models using variola and other orthopoxviruses --Genomic analysis --Development of therapeutics --Development of vaccines --Methods for detection and diagnosis.

The scarcity of laboratory facilities suitable and authorized for studying live variola virus is a serious constraint on the U.S. capability to undertake the research discussed in this report.

It would be possible to alter the variola virus genome to remove its capability for surviving outside the laboratory. Contents SUMMARY 1 1 INTRODUCTION 9 Overview of Scientific Needs for Live Variola Virus, 10 Current Status of Variola Virus and Materials, 12 Regulations and Other Guidance Pertaining to Countermeasures for Smallpox, 14 Study Charge and Approach, 15 Organization of the Report, 17 References, 17 2 OVERVIEW OF SMALLPOX AND ITS SURVEILLANCE AND CONTROL 19.

22 LIVE VARIOLA VIRUS TABLE â Timeline for Smallpox Eradication Date Location Event BC Survivors of smallpox called upon to care for the afflicted (as survivors were immune) Unknown Variolation, or inoculation, practiced in Africa, India, and China Europe and Live variola virus book method introduced North America Japan Variolation method.

Strains of a virus (e.g., variola major and variola minor) differ in their vimlence or ability to cause fatal disease. The differences in virulence may be due to changes in the rapidity of virus replication and spread, the amounts of vires produced, the ability to damage the cells in which the vires replicates, or the ability to evade the.

42 LIVE VARIOLA VIRUS cross-reactive response that is relevant for vaccine design and may suggest the characteristics of those responses that protected smallpox survivors from reinfection. Following vaccinia inoculation, antiviral T cell responses are difficult to detect at 1 week, but then rapidly expand and peak within approximately 2 weeks.

Variola virus. Variola virus (or variola major virus) is the virus that causes virus is one of the members of the poxvirus group (Family Poxviridae).The virus particle is brick shaped and contains a double strand of deoxyribonucleic variola virus is among the most dangerous of all the potential biological weapons.

Variola virus is the most complex of the orthopoxvirus genus, having many different strains(6,7). SECTION II – HAZARD IDENTIFICATION PATHOGENICITY/TOXICITY: Smallpox is an acute, contagious disease with two main forms, variola major and variola minor, both of.

The result of spread to these sites is the induction of cell-mediated and humoral immunity, and long-lived memory T and B cells that recognize the virus. Replication of variola virus is completely prevented for a few years, and thereafter replication is limited so that infection is subclinical, causing no symptoms.

Get this from a library. Live variola virus: considerations for continuing research. [Ann M Arvin; Deepali Patel; Institute of Medicine (U.S.). Committee on the Assessment of Future Scientific Needs for Live Variola Virus.;] -- Smallpox was a devastating disease that decimated human populations for centuries, and its eradication in was a monumental achievement for the global health.

Variola virus (the virus that causes smallpox) causes disease only in people. Other pox-like viruses, such as monkeypox, can infect both animals and people.

This unique characteristic of variola virus makes it an important virus to study and help us learn more about infectious diseases. Research using variola virus continues to expand our. More live coverage: The Latin name of the smallpox virus is Variola, and other strains of Variola are known.

Variola minor, which was eradicated along with smallpox (Variola major), caused a. Williams's book not only tells us about the history of smallpox before vaccination, and Jenner's discovery (and the disputes and battles surrounding it), but also the subsequent history of smallpox vaccination and resistance to it, up to the smallpox eradication campaign led by Donald Henderson.

This book is a joy to s: Examines whether the sequenced variola genome, vaccinia, and monkey pox virus are adequate for future research or whether the live variola virus itself is. Suggested Citation:"2 Variola Virus and Other Orthopoxviruses."Institute of Medicine. Assessment of Future Scientific Needs for Live Variola gton, DC:.

Examines whether the sequenced variola genome, vaccinia, and monkey pox virus are adequate for future research or whether the live variola virus itself is needed to assist in the development of antiviral therapies.

This book also examines what further benefits would likely be gained through the use of variola in research and development efforts. BoxConstitution Avenue, N.W., Washington, D.C., Call () or () (in the Washington metropolitan area), or visit the NAP online bookstore at The complete text of Assessment of Future Scientific Needs for Live Variola Virus is.

Examines whether the sequenced variola genome, vaccinia, and monkey pox virus are adequate for future research or whether the live variola virus itself is needed to assist in the development of This book also examines what further benefits would likely be gained through the use of variola in research and development efforts.

Although live variola virus has never been isolated from historical tissues, this finding does not eliminate the possibility of live variola virus resurfacing from well-preserved tissue material (10,12). Moreover, variola virus has been absent for >30 years, and there is an increasingly large population of susceptible persons who have never.

The committee appreciates the contributions of many individuals to this report. We express our gratitude to the experts who made presentations at the initial workshop: Mark Buller, Joseph Esposito, Donald A. Henderson, John Huggins, Peter Jahrling, Wolfgang Joklik, Sergei Shchelkunov, and Alan Zelicoff.

We also thank the workshop participants who contributed their insights and raised important.XIX Variola (Smallpox) Variola virus, which causes smallpox, is no longer found in nature in any part of the world but is still feared as a bioterrorism agent.

There is no effective drug for smallpox, and the length of protection afforded by the existing smallpox vaccine (based on live, attenuated vaccinia virus) is .The study titled, ‘Diverse variola virus (smallpox) strains were widespread in northern Europe in the Viking Age’, was published in the Science journal last week.

The researchers screened DNA collected from the skeletal and dental remains of individuals who lived in Eurasia and America betw and years ago, to locate the.